The southeastern US, specifically Alabama, Georgia, Florida, Mississippi, and South Carolina, is a relatively stable geological area of the North American craton, and because this is a significant consideration regarding deep borehole waste storage or disposal operations, the potential for this activity is discussed herein. Using a set of siting criteria for deep borehole storage and disposal operations recently published by the US Department of Energy (DOE), we show that there are significant areas of the southeastern US having bedrock of various lithic types that are likely acceptable for waste storage and disposal at appropriate, yet at relatively shallow depths. These DOE siting criteria are that the specific area under consideration (1) has relatively shallow aquifers and aquifer systems that can be avoided by choosing appropriate disposal locations; (2) is not near any shear zones, stress fields, or tectonic features; (3) is lacking in seismicity (the primary southeastern US exception is the Charleston, South Carolina, earthquake zone); (4) is devoid of relatively recent (Quaternary) volcanism and fault activity and very low in geothermal activity; and  (5) is situated at a suitable distance from significant human development, petroleum drilling activity, and existing sites of and sources for human-produced radioactive contamination.This paper addresses the geological siting criteria for deep storage or disposal boreholes within the region’s main geological terrains and addresses the key types of rocks within each terrain (specifically crystalline rocks, shale formations, and rock salt bodies), which are generally agreed to have characteristics best suited to hosting deep borehole storage or disposal operations.